Musiq was born in Philadelphia, Pennsylvania and is the oldest of nine children. At an early age, Musiq decided he would drop out of high school, and left home at 17. It was during that time Musiq started to build a reputation for being musically gifted, beat boxing for MC's, free styling on the open mic circuit, scatting at a jazz club, or just performing a cappella in the streets of Philadelphia, which is where he got the name "Musiq" and later added "Soulchild", which is intended to respect and represent the legacy and traditions of past soul artists.
Musiq Soulchild released his debut album, Aijuswanaseing, in 2000. Its lead single was "Just Friends (Sunny)". Musiq's second single "Love" spent 22 weeks on the Billboard Hot 100 charts. Musiq’s second album, 2002's Juslisen, debuted at number 1 on the Billboard Charts and went platinum. The singles were "Halfcrazy" and "Dontchange".
In 2003, Musiq released his 3rd album, Soulstar. It included the singles "Forthenight" and "Whoknows". Musiq took a four year break and changed his management to Solqi Management; as well as his record label from Def Soul to Atlantic Records.
In March 2007, Musiq's released his fourth album Luvanmusiq. Its singles were "B.U.D.D.Y.", "Teachme", and "Makeyouhappy". His fifth album OnMyRadio was released on December 2, 2008. The lead single "Radio" was a complete contrast to the usual smooth soul and R&B Musiq fans were accustomed to. The following singles were the duet "IfULeave" featuring Mary J. Blige; and the ballad "SoBeautiful". "SoBeautiful" marked the first collaboration between Musiq and the producer JR Hutson, after Hutson had spent "about eight months" trying to get Musiq to come by his studio. According to Hutson, the two plan to work together again.
His sixth album Musiqinthemajiq was released on May 3, 2011, available on CDs and also as a digital download. The first single is Anything featuring Swizz Beatz.